Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.

Bibliographic Details
Main Authors: Seung Hyun Lee, Nayoung Kim, Minkyu Kim, Sang-Ho Woo, Inhee Han, Jisu Park, Kyeongdae Kim, Kyu Seong Park, Kibyeong Kim, Dahee Shim, Sang-eun Park, Jing Yu Zhang, Du-Min Go, Dae-Yong Kim, Won Kee Yoon, Seung-Pyo Lee, Jongsuk Chung, Ki-Wook Kim, Jung Hwan Park, Sak Lee, Soo-jin Ann, Sang-Hak Lee, Hyo-Suk Ahn, Seong Cheol Jeong, Tae Kyeong Kim, Goo Taeg Oh, Woong-Yang Park, Hae-Ock Lee, Jae-Hoon Choi
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33202-2

Internet

https://doi.org/10.1038/s41467-022-33202-2

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