Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.

The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), whose pivotal role on innate immune responses against RNA viruses is being increasingly uncovered. LGP2 is known to work in synergy with mela...

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Bibliographic Details
Main Authors: Miguel Rodríguez Pulido, María Teresa Sánchez-Aparicio, Encarnación Martínez-Salas, Adolfo García-Sastre, Francisco Sobrino, Margarita Sáiz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6042790?pdf=render

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http://europepmc.org/articles/PMC6042790?pdf=render

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