Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies

Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies

Abstract Background The rule of thumb that there is little gain in statistical power by obtaining more than 4 controls per case, is based on type-1 error α = 0.05. However, association studies that evaluate thousands or millions of associations use smaller α and may have access to plentiful controls...

Full description

Bibliographic Details
Main Authors: Hormuzd A. Katki, Sonja I. Berndt, Mitchell J. Machiela, Douglas R. Stewart, Montserrat Garcia-Closas, Jung Kim, Jianxin Shi, Kai Yu, Nathaniel Rothman
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Medical Research Methodology
Subjects:
Control selection
Multiple comparisons
Study design
Molecular epidemiology
Online Access:https://doi.org/10.1186/s12874-023-01973-x

Internet

https://doi.org/10.1186/s12874-023-01973-x

Similar Items