Replication Timing Aberration of KIF14 and MDM4/PI3KC2β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients

Replication Timing Aberration of KIF14 and MDM4/PI3KC2β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients

Replication timing of allelic gene pairs is strictly regulated according to expression, genome stability, and epigenetic changes, and tumorigenesis may be associated with changes in the allelic replication in various tumors. Our aim was to determine whether such alterations had a prognostic value in...

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Bibliographic Details
Main Authors: Fernanda Rocha Rojas Ayala, Jeffrey William Martin, Carmen Silvia Bertuzzo
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2023-06-01
Series:Global Medical Genetics
Subjects:
replication timing
aneuploidy
chromosomal instability
poor treatment response
ewing sarcoma
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768238

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768238

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