Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by degradation of preexisting proteins by the proteasome. However, the specific su...

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Bibliographic Details
Main Authors: Gabriela Vargas, Omar Cortés, Eloisa Arias-Muñoz, Sergio Hernández, Cristobal Cerda-Troncoso, Laura Hernández, Alexis E. González, Michael H. Tatham, Hianara A. Bustamante, Claudio Retamal, Jorge Cancino, Manuel Varas-Godoy, Ronald T. Hay, Alejandro Rojas-Fernández, Viviana A. Cavieres, Patricia V. Burgos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HERPUD1
ubiquitin-like (UBL) domain
organelle network
lysosomal function
proteostais
MCSs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.743287/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.743287/full

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