Maintenance of Hypoimmunogenic Features via Regulation of Endogenous Antigen Processing and Presentation Machinery

Maintenance of Hypoimmunogenic Features via Regulation of Endogenous Antigen Processing and Presentation Machinery

Universally acceptable donor cells have been developed to address the unmet need for immunotypically matched materials for regenerative medicine. Since forced expression of hypoimmunogenic genes represses the immune response, we established universal pluripotent stem cells (PSCs) by replacing endoge...

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Bibliographic Details
Main Authors: Ju-Hyun An, Hyebin Koh, Yujin Ahn, Jieun Kim, A-Reum Han, Ji Yoon Lee, Sun-Uk Kim, Jong-Hee Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hypoimmunogenic cell
universal donor cell
regenerative cell therapy
antigen presentation and processing machinery
cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.936584/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.936584/full

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