Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis

Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis

Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity an...

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Bibliographic Details
Main Authors: Nina Rößler, Tassilo Jungenitz, Albrecht Sigler, Alexander Bird, Martin Mittag, Jeong Seop Rhee, Thomas Deller, Hermann Cuntz, Nils Brose, Stephan W. Schwarzacher, Peter Jedlicka
Format: Article
Language:English
Published: The Royal Society 2023-08-01
Series:Open Biology
Subjects:
lognormal distribution
heterosynaptic plasticity
Munc13 double-knockout mice
multiplicative noise
intrinsic/extrinsic synaptic dynamics
spike-timing-dependent plasticity (STDP)
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230063

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https://royalsocietypublishing.org/doi/10.1098/rsob.230063

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