Combinations of scleroderma hallmark autoantibodies associate with distinct clinical phenotypes

Abstract Systemic sclerosis (SSc) is characterized by the presence of SSc-specific or SSc-associated antibodies (SSc-Abs): anti-topoisomerase I (ATA), anti-centromere (ACA), anti-RNA polymerase III (ARA), anti-U3RNP (U3RNP), anti-U1RNP (U1RNP), anti-PmScl (PmScl), anti-Ku (Ku) and anti-Th/To (Th/To)...

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Bibliographic Details
Main Authors: Kristina E. N. Clark, Corrado Campochiaro, Lauren V. Host, Alper Sari, Jennifer Harvey, Christopher P. Denton, Voon H. Ong
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15062-4