Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome ortholog mutants of Saccharomyces cerevisiae

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome ortholog mutants of Saccharomyces cerevisiae

Summary: Ribonucleoside monophosphates (rNMPs) are abundantly found within genomic DNA of cells. The embedded rNMPs alter DNA properties and impact genome stability. Mutations in ribonuclease (RNase) H2, a key enzyme for rNMP removal, are associated with the Aicardi-Goutières syndrome (AGS), a sever...

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Bibliographic Details
Main Authors: Deepali L. Kundnani, Taehwan Yang, Alli L. Gombolay, Kuntal Mukherjee, Gary Newnam, Chance Meers, Ishika Verma, Kirti Chhatlani, Zeel H. Mehta, Celine Mouawad, Francesca Storici
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:iScience
Subjects:
nucleic acids
genomics
molecular genetics
model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224012379

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http://www.sciencedirect.com/science/article/pii/S2589004224012379

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