Protective Effect of Tetrahydrobiopterin Against Reactive Oxygen Species- and Nitric Oxide-induced Vascular Endothelial Cell Injury

Protective Effect of Tetrahydrobiopterin Against Reactive Oxygen Species- and Nitric Oxide-induced Vascular Endothelial Cell Injury

Vascular endothelial cells are one of the major biological targets of reactive oxygen species (ROS) in ischemiareperfusion, diabetes, hypercholesterolemia and inflammation. Accumulated evidence has shown that tetrahydrobiopterin (BH4), which is an essential cefactor for nitric oxide synthase (NOS) a...

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Bibliographic Details
Main Author: Shimizu Shunichi
Format: Article
Language:English
Published: De Gruyter 2002-02-01
Series:Pteridines
Subjects:
nitric oxide synthase
nitric oxide
hydrogen peroxide
tetrahydrobiopterin
endothelial cells
cell injury
Online Access:https://doi.org/10.1515/pteridines.2002.13.1.32

Internet

https://doi.org/10.1515/pteridines.2002.13.1.32

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