SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

Abstract Background Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyrosine phosphatase (PTPs), which play a significant role in maintaining...

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Bibliographic Details
Main Authors: Jihong Jiang, Baoji Hu, Chun-Shiang Chung, Yaping Chen, Yunhe Zhang, Elizabeth W. Tindal, Jinbao Li, Alfred Ayala
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Medicine
Subjects:
SHP2
Acute kidney injury
PHPS1
Erk1/2
STAT3
Phosphatase inhibition
Online Access:http://link.springer.com/article/10.1186/s10020-020-00210-1

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http://link.springer.com/article/10.1186/s10020-020-00210-1

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