Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

Abstract Background Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations. Non-random variation in the treatment effect of an intervention due to differences in the baseline risk of death between pati...

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Bibliographic Details
Main Authors: Shalini Santhakumaran, Anthony Gordon, A. Toby Prevost, Cecilia O’Kane, Daniel F. McAuley, Manu Shankar-Hari
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Critical Care
Subjects:
Sepsis, acute respiratory distress syndrome
Models, statistical
Randomisation
Risk
Study design
Online Access:http://link.springer.com/article/10.1186/s13054-019-2446-1

Internet

http://link.springer.com/article/10.1186/s13054-019-2446-1

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