Nicotinamide Phosphoribosyltransferase‐elevated NAD+ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

Nicotinamide Phosphoribosyltransferase‐elevated NAD+ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction

Abstract Background It is well known that muscle disuse atrophy is associated with mitochondrial dysfunction, which is implicated in reduced nicotinamide adenine dinucleotide (NAD+) levels. Nicotinamide phosphoribosyltransferase (NAMPT), a rate‐limiting enzyme in NAD+ biosynthesis, may serve as a no...

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Bibliographic Details
Main Authors: Yao Zhang, Yingming Wang, Shuai Lu, Rui Zhong, Zhilin Liu, Qichun Zhao, Chongyang Wang
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Muscle disuse atrophy
Mitochondrial dysfunction
NAMPT
Rotator cuff tear
Fatty infiltration
Online Access:https://doi.org/10.1002/jcsm.13182

Internet

https://doi.org/10.1002/jcsm.13182

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