Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats
Objective To investigate the role of the deubiquitinase ubiquitin C-terminal hydrolase L1 (UCHL1) in hypertension and retinopathy in the spontaneously hypertensive rat (SHR). Methods Wistar–Kyoto (WKY) rats and SHRs were administered the UCHL1 inhibitor LDN57444 (20 μg/kg/day) for 4 months. Patholog...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211020641 |