Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293

Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293

Coupling glycolysis and mitochondrial tricarboxylic acid cycle, pyruvate dehydrogenase (PDH) complex (PDHC) is highly responsive to cellular demands through multiple mechanisms, including PDH phosphorylation. PDHC also produces acetyl-CoA for protein acetylation involved in circadian regulation of m...

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Bibliographic Details
Main Authors: Vasily A. Aleshin, Artem V. Artiukhov, Thilo Kaehne, Anastasia V. Graf, Victoria I. Bunik
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
brain proteins acetylation
diurnal regulation
pyruvate dehydrogenase
PDHA phosphorylation
SIRT2
SIRT3
Online Access:https://www.mdpi.com/1422-0067/22/15/8006

Internet

https://www.mdpi.com/1422-0067/22/15/8006

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