GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neur...

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Bibliographic Details
Main Authors: Alondra Schweizer Burguete, Sandra Almeida, Fen-Biao Gao, Robert Kalb, Michael R Akins, Nancy M Bonini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
c9orf72
GGGGCC
spinal cord neurons
ALS
FTD
FMRP
Online Access:https://elifesciences.org/articles/08881

Internet

https://elifesciences.org/articles/08881

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