Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction

Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction

Myeloperoxidase (MPO) is a highly oxidative, pro-inflammatory enzyme involved in post-myocardial infarction (MI) injury and is a potential therapeutic target. While multiple MPO inhibitors have been developed, the lack of an imaging reporter to select appropriate patients and assess therapeutic effi...

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Bibliographic Details
Main Authors: Matthias W. G. Zeller, Cuihua Wang, Edmund J. Keliher, Gregory R. Wojtkiewicz, Aaron Aguirre, Kevin Maresca, Chunyan Su, Leonard Buckbinder, Jing Wang, Matthias Nahrendorf, John W. Chen
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
myeloperoxidase
PET imaging
<sup>18</sup>F-MAPP
damaging inflammation
myocardial infarction
intracellular and extracellular MPO
Online Access:https://www.mdpi.com/1422-0067/24/6/5704

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https://www.mdpi.com/1422-0067/24/6/5704

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