Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

Abnormalities in nucleic acid processing are associated with the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin 3 (MATR3), a poorly understood DNA- and RNA-binding protein, cause familial ALS/FTD, and MATR3 pathology is a feature of sporadic...

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Bibliographic Details
Main Authors: Ahmed M Malik, Roberto A Miguez, Xingli Li, Ye-Shih Ho, Eva L Feldman, Sami J Barmada
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
ALS
FTD
RNA binding protein
neurodegeneration
Online Access:https://elifesciences.org/articles/35977

Internet

https://elifesciences.org/articles/35977

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