Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury

Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury

FXR regulates bile acid metabolism, and FXR null (Fxr−/−) mice have elevated bile acid levels and progressive liver injury. The inositol-requiring enzyme 1α/X-box binding protein 1 (XBP1) pathway is a protective unfolded protein response pathway activated in response to endoplasmic reticulum stress....

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Bibliographic Details
Main Authors: Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Lipid Research
Subjects:
bile acids
bile salts
apoptosis
cell signaling
inflammation
unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001225

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http://www.sciencedirect.com/science/article/pii/S0022227522001225

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