Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy

Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy

IntroductionThe purpose of this study was to evaluate recombinant human endostatin (rHE)-induced normalization of the tumor vasculature in colorectal cancer (CRC) and to evaluate the therapeutic effects of combined treatment with rHE and a programmed death ligand-1 (PD-L1) inhibitor.MethodsA mouse s...

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Bibliographic Details
Main Authors: Xiao-Dong Chu, Hui Bao, Yu-Jian Lin, Ruo-Xi Chen, Yi-Ran Zhang, Ting Huang, Jia-Shuai He, Shu-Chen Huangfu, Yun-Long Pan, Hui Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
recombinant human endostatin
PD-L1 inhibitor
tumor vascular normalization
CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.965492/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.965492/full

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