<i>ALDH1L2</i> Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency

<i>ALDH1L2</i> Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency

Previously, the in vitro growth of cancer stem cells in the form of tumor spheres from five different brain cancer cell lines was found to be methionine-dependent. As this earlier work indicated that <i>ALDH1L2</i>, a folate-dependent mitochondria aldehyde dehydrogenase gene, is upregula...

Full description

Bibliographic Details
Main Authors: Maëlle Quéré, Jean-Marc Alberto, Franck Broly, Sébastien Hergalant, Christo Christov, Guillaume Gauchotte, Jean-Louis Guéant, Farès Namour, Shyue-Fang Battaglia-Hsu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
tumor sphere
glioblastoma
methionine
ROS
<i>ALDH1L2</i>
Online Access:https://www.mdpi.com/2072-6643/14/9/1887

Internet

https://www.mdpi.com/2072-6643/14/9/1887

Similar Items