Flexible NAD<sup>+</sup> Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A

Flexible NAD<sup>+</sup> Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A

The eukaryotic and archaeal translation factor IF5A requires a post-translational hypusine modification, which is catalyzed by deoxyhypusine synthase (DHS) at a single lysine residue of IF5A with NAD<sup>+</sup> and spermidine as cofactors, followed by hydroxylation to form hypusine. Whi...

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Bibliographic Details
Main Authors: Meirong Chen, Zuoqi Gai, Chiaki Okada, Yuxin Ye, Jian Yu, Min Yao
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
IF5A
translation factor
hypusine modification
deoxyhypusine synthase
structure
NAD<sup>+</sup>
Online Access:https://www.mdpi.com/1422-0067/21/15/5509

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https://www.mdpi.com/1422-0067/21/15/5509

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