Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer’s disease

In this issue of the JCI, Wang and colleagues investigate the relationship between sleep disturbances, an environmental risk factor for Alzheimer’s disease (AD), and the apolipoprotein 4 (APOEε4) allele, a strong genetic risk factor for AD. The authors subjected an amyloid mouse model expressing hum...

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Bibliographic Details
Main Authors: Katherine R. Sadleir, Robert Vassar
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-07-01
Series:The Journal of Clinical Investigation
Online Access:https://doi.org/10.1172/JCI171838