Incorporation of a TGF-β2-inhibiting oligodeoxynucleotide molecular adjuvant into a tumor cell lysate vaccine to enhance antiglioma immunity in mice

Incorporation of a TGF-β2-inhibiting oligodeoxynucleotide molecular adjuvant into a tumor cell lysate vaccine to enhance antiglioma immunity in mice

IntroductionTransforming growth factor β2 (TGF-β2), also known as glioma-derived T-cell suppressor factor, is associated with the impairment of tumor immune surveillance. Therefore, blocking TGF-β2 signaling probably be a feasible strategy to develop a novel type of adjuvant for glioma vaccines to e...

Full description

Bibliographic Details
Main Authors: Liqun Tu, Zhe Wang, Lei Yang, Xiaomeng Sun, Yunpeng Yao, Peng Zhang, Xiaotian Zhang, Liying Wang, Yongli Yu, Ming Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
adjuvant
tumor vaccines
TGF-β2
inhibitory oligodeoxynucleotide
glioma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1013342/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1013342/full

Similar Items