Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma

Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma

Summary: To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organoids and compared with those from healthy...

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Main Authors: Maciej Daniszewski, Anne Senabouth, Helena H. Liang, Xikun Han, Grace E. Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E. Clarke, Shiang Y. Lim, Jarmon G. Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L. Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A. McCloy, Linda Clarke, Lisa S. Kearns, David A. Mackey, Jamie E. Craig, Stuart MacGregor, Joseph E. Powell, Alice Pébay, Alex W. Hewitt
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Genomics
Subjects:
human induced pluripotent stem cells
retinal organoids
retinal ganglion cells
single-cell RNA sequencing
glaucoma
transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22000751

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http://www.sciencedirect.com/science/article/pii/S2666979X22000751

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