A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A

The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic. Due to these limitations, a recombinant monoclonal antibody (mAb)...

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Bibliographic Details
Main Authors: Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
bi-epitopic
tri-epitopic
multivalent antibody
recombinant monoclonal antibody
botulinum neurotoxin
antitoxin
botulism
mouse neutralization assay
negative-stain electron microscopy
kinetic-exclusion analysis
Online Access:http://www.mdpi.com/2072-6651/10/2/84

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http://www.mdpi.com/2072-6651/10/2/84

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