SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces fatty acid (FA) oxidation. Here, we identified 17 individuals with SEMA7A heterozygous mutations in 470 patients with biopsy...

Full description

Bibliographic Details
Main Authors: Nan Zhao, Xiaoxun Zhang, Jingjing Ding, Qiong Pan, Ming-Hua Zheng, Wen-Yue Liu, Gang Luo, Jiaquan Qu, Mingqiao Li, Ling Li, Ying Cheng, Ying Peng, Qiaoling Xie, Qinglin Wei, Qiao Li, Lingyun Zou, Xinshou Ouyang, Shi-Ying Cai, James L. Boyer, Jin Chai
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-08-01
Series:JCI Insight
Subjects:
Hepatology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.154113

Internet

https://doi.org/10.1172/jci.insight.154113

Similar Items