Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation

Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation

Abstract Adaptive immunity is critical for disease progression and modulates T cell (TC) and antigen-presenting cell (APC) functions. Three signals were initially proposed for adaptive immune activation: signal 1 antigen recognition, signal 2 co-stimulation or co-inhibition, and signal 3 cytokine st...

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Bibliographic Details
Main Authors: Jin Dai, Pu Fang, Jason Saredy, Hang Xi, Cueto Ramon, William Yang, Eric T. Choi, Yong Ji, Wei Mao, Xiaofeng Yang, Hong Wang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Hematology & Oncology
Subjects:
Immune checkpoint
Metabolism-associated danger signal
Metabolic risk factors
Reverse-immune checkpoint
CD40+ MC
Online Access:http://link.springer.com/article/10.1186/s13045-017-0504-1

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http://link.springer.com/article/10.1186/s13045-017-0504-1

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