Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice

Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice

Influenza virus hemagglutinin (HA) stem is currently regarded as an extremely promising immunogen for designing universal influenza vaccines. The appropriate antigen-presenting vaccine vector would be conducive to increasing the immunogenicity of the HA stem antigen. In this study, we generated chim...

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Bibliographic Details
Main Authors: Cui-Cui Liu, De-Jian Liu, Xin-Yu Yue, Xiu-Qin Zhong, Xuan Wu, Hai-Yan Chang, Bao-Zhong Wang, Mu-Yang Wan, Lei Deng
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Viruses
Subjects:
influenza virus
hemagglutinin stem
virus-like particle
DnaK
universal vaccine
Online Access:https://www.mdpi.com/1999-4915/14/10/2109

Internet

https://www.mdpi.com/1999-4915/14/10/2109

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