PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

Abstract Background Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear. Here, we report a protective role of polo-like kinase 1 (PLK1) in intestinal barrier in...

Full description

Bibliographic Details
Main Authors: Ying-Ya Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-Na Wu, Li-Li Wu, Kai Song, Wei-Hua Lu, Jian-Bo Yu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Medicine
Subjects:
Sepsis
Intestinal barrier
Apoptosis
Mitochondrial dynamics
PLK1
TANK
Online Access:https://doi.org/10.1186/s10020-022-00597-z

Internet

https://doi.org/10.1186/s10020-022-00597-z

Similar Items