Notochordal-Cell-Derived Exosomes Induced by Compressive Load Inhibit Angiogenesis via the miR-140-5p/Wnt/β-Catenin Axis

Notochordal-Cell-Derived Exosomes Induced by Compressive Load Inhibit Angiogenesis via the miR-140-5p/Wnt/β-Catenin Axis

Angiogenesis is a pathological signature of intervertebral disc degeneration (IDD). Accumulating evidence has shown that notochordal cells (NCs) play an essential role in maintaining intervertebral disc development and homeostasis with inhibitive effect on blood vessel in-growth. However, the anti-a...

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Bibliographic Details
Main Authors: Zhen Sun, Bing Liu, Zhi-Heng Liu, Wen Song, Dong Wang, Bei-Yu Chen, Jing Fan, Zhe Xu, Dan Geng, Zhuo-Jing Luo
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
intervertebral disc
notochordal cell
exosome
angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303334

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http://www.sciencedirect.com/science/article/pii/S2162253120303334

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