DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Summary: Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in oral squamous cell carcinoma (OSCC) cells. Ribo-seq analysis confirmed amphiregulin (AREG) as a translational target of DDX3. AREG exerts important biological functions in ca...

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Bibliographic Details
Main Authors: Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221010543

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221010543

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