Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

In this work, Blair and co-authors used cryo-EM and in vitro assays to show that human Ligase 1 (Lig1) and Flap Endonuclease 1 (FEN1) form a toolbelt with the sliding clamp PCNA coordinating the sealing of Okazaki fragments.

Bibliographic Details
Main Authors: Kerry Blair, Muhammad Tehseen, Vlad-Stefan Raducanu, Taha Shahid, Claudia Lancey, Fahad Rashid, Ramon Creuhet, Samir M. Hamdan, Alfredo De Biasio
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35475-z

Internet

https://doi.org/10.1038/s41467-022-35475-z

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