Threonine Phosphorylation of an Electrochemical Peptide-Based Sensor to Achieve Improved Uranyl Ion Binding Affinity

Threonine Phosphorylation of an Electrochemical Peptide-Based Sensor to Achieve Improved Uranyl Ion Binding Affinity

We have successfully designed a uranyl ion (U(VI)-specific peptide and used it in the fabrication of an electrochemical sensor. The 12-amino acid peptide sequence, (n) DKDGDGYIpTAAE (c), originates from calmodulin, a Ca(II)-binding protein, and contains a phosphothreonine that enhances the sequence’...

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Bibliographic Details
Main Authors: Channing C. Thompson, Rebecca Y. Lai
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biosensors
Subjects:
calmodulin
electrochemical metal ion sensor
peptide design
phosphothreonine
self-assembled monolayer
uranyl ion
Online Access:https://www.mdpi.com/2079-6374/12/11/961

Internet

https://www.mdpi.com/2079-6374/12/11/961

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