Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing

Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing

The recent therapeutic success of immune checkpoint inhibitors in the treatment of advanced melanoma highlights the potential of cancer immunotherapy. Oncolytic virus-based therapies may further improve the outcome of these cancer patients. A human ex vivo melanoma model was used to investigate the...

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Bibliographic Details
Main Authors: Katrin Goepfert, Christiane Dinsart, Jean Rommelaere, Friedrich Foerster, Markus Moehler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
melanoma
immune cells
H-1PV
nivolumab
ipilimumab
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00425/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00425/full

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