Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and p...

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Bibliographic Details
Main Authors: Bhupendra Raj Giri, Jung Suk Kim, Jong Hyuck Park, Sung Giu Jin, Kyeong Soo Kim, Fakhar ud Din, Han Gon Choi, Dong Wuk Kim
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
methotrexate
solid dispersion
solubility
bioavailability
photostability
Online Access:https://www.mdpi.com/1999-4923/13/1/111

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https://www.mdpi.com/1999-4923/13/1/111

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