Mn(III) Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress

Mn(III) Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress

Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective effects of MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001), a superoxide dismutase mimic, in an in vitro model of I/R injury in H9c2 cardiomyocy...

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Bibliographic Details
Main Authors: Sudha Sharma, Papori Sharma, Utsab Subedi, Susmita Bhattarai, Chloe Miller, Shrivats Manikandan, Ines Batinic-Haberle, Ivan Spasojevic, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
superoxide
cardiomyocytes
SOD2
apoptosis
Online Access:https://www.mdpi.com/1422-0067/24/7/6159

Internet

https://www.mdpi.com/1422-0067/24/7/6159

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