DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

Genome instability is a hallmark of aging and contributes to age-related disorders such as cancer and Alzheimer’s disease. The accumulation of DNA damage during aging has been linked to altered cell cycle dynamics and the failure of cell cycle checkpoints. Here, we use single cell imaging to study t...

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Bibliographic Details
Main Authors: Matthew M Crane, Adam E Russell, Brent J Schafer, Ben W Blue, Riley Whalen, Jared Almazan, Mung Gi Hong, Bao Nguyen, Joslyn E Goings, Kenneth L Chen, Ryan Kelly, Matt Kaeberlein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
aging
replicative lifespan
senescence
extrachromosomal rDNA circles
microfluidics
histones
Online Access:https://elifesciences.org/articles/50778

Internet

https://elifesciences.org/articles/50778

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