The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young animals

Bibliographic Details
Main Authors: Caroline Beaudoin-Chabot, Lei Wang, Cenk Celik, Aishah Tul-Firdaus Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus Wen Xuan Lim, Ann Don Low, Guillaume Thibault
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33630-0

Internet

https://doi.org/10.1038/s41467-022-33630-0

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