Evaluating the clinical impact of routine whole genome sequencing in tuberculosis treatment decisions and the issue of isoniazid mono-resistance

Evaluating the clinical impact of routine whole genome sequencing in tuberculosis treatment decisions and the issue of isoniazid mono-resistance

Abstract Background The UK has implemented routine use of whole genome sequencing (WGS) in TB diagnostics. The WHO recommends addition of a fluoroquinolone for isoniazid mono-resistance, so early detection may be of use. The aim of this study was to describe the clinical utility and impact of WGS on...

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Bibliographic Details
Main Authors: Mirae Park, Ajit Lalvani, Giovanni Satta, Onn Min Kon
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Infectious Diseases
Subjects:
Whole genome sequencing
Tuberculosis
Treatment alteration
Turnaround times
Isoniazid mono-resistance
Online Access:https://doi.org/10.1186/s12879-022-07329-y

Internet

https://doi.org/10.1186/s12879-022-07329-y

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