SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancerResearch in context

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancerResearch in context

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterised by extensive matrix deposition that has been implicated in impaired drug delivery and therapeutic resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that regulates collagen deposition and is...

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Main Authors: Iswarya Ramu, Sören M. Buchholz, Melanie S. Patzak, Robert G. Goetze, Shiv K. Singh, Frances M. Richards, Duncan I. Jodrell, Bence Sipos, Philipp Ströbel, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419306280

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http://www.sciencedirect.com/science/article/pii/S2352396419306280

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