Store-Operated Calcium Entry Inhibition and Plasma Membrane Calcium Pump Upregulation Contribute to the Maintenance of Resting Cytosolic Calcium Concentration in A1-like Astrocytes

Store-Operated Calcium Entry Inhibition and Plasma Membrane Calcium Pump Upregulation Contribute to the Maintenance of Resting Cytosolic Calcium Concentration in A1-like Astrocytes

Highly neurotoxic A1-reactive astrocytes have been associated with several human neurodegenerative diseases. Complement protein C3 expression is strongly upregulated in A1 astrocytes, and this protein has been shown to be a specific biomarker of these astrocytes. Several cytokines released in neurod...

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Bibliographic Details
Main Authors: Joana Poejo, María Berrocal, Lucía Saez, Carlos Gutierrez-Merino, Ana M. Mata
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
A1 astrocytes
complement component C3
amyloid β
cytosolic calcium
intracellular calcium homeostasis
store-operated calcium entry
Online Access:https://www.mdpi.com/1420-3049/28/14/5363

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https://www.mdpi.com/1420-3049/28/14/5363

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