Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation between galactosylation and CDC has been known, the unde...

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Váldodahkkit: Bingchuan Wei, Xuan Gao, Lance Cadang, Saeed Izadi, Peilu Liu, Hui-Min Zhang, Elizabeth Hecht, Jeongsup Shim, Gordon Magill, Juan Rincon Pabon, Lu Dai, Wilson Phung, Elaine Lin, Christopher Wang, Kevin Whang, Sean Sanchez, Jose Oropeza Jr, Julien Camperi, Jennifer Zhang, Wendy Sandoval, Yonghua Taylor Zhang, Guoying Jiang
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Taylor & Francis Group 2021-01-01
Ráidu:mAbs
Fáttát:
monoclona antibody; IgG1
galactosylation
CDC; CHO Cell Culture
CQA; mass Spectrometry
kinetics
Liŋkkat:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893427

Interneahtta

https://www.tandfonline.com/doi/10.1080/19420862.2021.1893427

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