Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Abstract Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing. The levels and complexity of CDD increases with linear energy transfer (L...

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Bibliographic Details
Main Authors: Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06541-9

Internet

https://doi.org/10.1038/s41419-024-06541-9

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