Expression of a Constitutively Active Form of <i>Hck</i> in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice

Expression of a Constitutively Active Form of <i>Hck</i> in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice

Runx2 is required for chondrocyte proliferation and maturation. In the search of Runx2 target genes in chondrocytes, we found that Runx2 up-regulated the expression of hematopoietic cell kinase (<i>Hck)</i>, which is a member of the Src tyrosine kinase family, in chondrocytes, that <i...

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Bibliographic Details
Main Authors: Viviane K. S. Kawata Matsuura, Carolina Andrea Yoshida, Hisato Komori, Chiharu Sakane, Kei Yamana, Qing Jiang, Toshihisa Komori
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Hck
Runx2
chondrocyte proliferation
Wnt
hedgehog
Online Access:https://www.mdpi.com/1422-0067/21/8/2682

Internet

https://www.mdpi.com/1422-0067/21/8/2682

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