Synthesis and Antimalarial Evaluation of New 1,3,5-<i>tris</i>[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold

Synthesis and Antimalarial Evaluation of New 1,3,5-<i>tris</i>[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold

A series of new 1,3,5-<i>tris</i>[(4-(substituted-aminomethyl)phenyl)methyl]benzene compounds were designed, synthesized, and evaluated <i>in vitro</i> against two parasites (<i>Plasmodium falciparum</i> and <i>Leishmania donovani</i>). The biological...

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Bibliographic Details
Main Authors: Sandra Albenque-Rubio, Jean Guillon, Anita Cohen, Patrice Agnamey, Solène Savrimoutou, Stéphane Moreau, Jean-Louis Mergny, Luisa Ronga, Ioannis Kanavos, Serge Moukha, Pascale Dozolme, Pascal Sonnet
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Drugs and Drug Candidates
Subjects:
antimalarial activity
1,3,5-<i>tris</i>[(4-(substituted-aminomethyl)phenyl)methyl]benzene
antileishmanial activity
Online Access:https://www.mdpi.com/2813-2998/2/3/33

Internet

https://www.mdpi.com/2813-2998/2/3/33

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