Targeted inhibition of STAT3 (Tyr705) by xanthatin alleviates osteoarthritis progression through the NF-κB signaling pathway

Targeted inhibition of STAT3 (Tyr705) by xanthatin alleviates osteoarthritis progression through the NF-κB signaling pathway

The transcription factor, signal transducer, and stimulator of transcription 3 (STAT3) is a potential target in osteoarthritis (OA) treatment. Although xanthatin (XA), a biologically active substance derived from Xanthium strumarium L, specifically inhibits STAT3 phosphorylation at Tyr705, the mecha...

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Bibliographic Details
Main Authors: Yangjun Xu, Zhuolin Chen, Xuanyuan Lu, Jiewen Zheng, Xuewen Liu, Tan Zhang, Wanlei Yang, Yu Qian
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
xanthatin
chondrocytes
osteoclasts
STAT3 Tyr705
osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003354

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http://www.sciencedirect.com/science/article/pii/S0753332224003354

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