Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit

Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit

BackgroundFexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction. Inverse agonists may be more potent than neutral antagonists, as they bind the same receptor as the agonist (HIS) but stabilize the inactiv...

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Bibliographic Details
Main Authors: Anne Barbot, Michele Lheritier-Barrand, Margarita Murrieta-Aguttes, Maud Leonetti, Jimmy Vernaz, Song Huang, Samuel Constant, Bernadett Boda
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
inflammation
allergy
nasal epithelium
antihistamine
fexofenadine
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1393702/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1393702/full

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