Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation

Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation

Abstract Background Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about 25% of FMC patients. However, the mechanism underlying hepatic metasta...

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Bibliographic Details
Main Authors: Yi-Chih Chang, Hao-Ping Liu, Hsiao-Li Chuang, Jiunn-Wang Liao, Pei-Ling Kao, Hsun-Lung Chan, Ter-Hsin Chen, Yu-Chih Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Laboratory Animal Research
Subjects:
Extracellular vesicle
Sphingosine kinase-1
Pre-metastatic niche
Feline mammary carcinoma
Hepatic stellate cell
Online Access:https://doi.org/10.1186/s42826-023-00180-5

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