Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties

Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties

ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration. Nonetheless, ACKR2 regulates inflammatory and immune responses by shaping chemokine gradients in ti...

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Bibliographic Details
Main Authors: Alessandro Vacchini, Elisa Maffioli, Dario Di Silvestre, Cinzia Cancellieri, Samantha Milanesi, Simona Nonnis, Sabrina Badanai, Pierluigi Mauri, Armando Negri, Massimo Locati, Gabriella Tedeschi, Elena Monica Borroni
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
ACKR2
CCR5
signaling
SILAC
phosphoproteome
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1060555/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1060555/full

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